Irreversible Atg 8 Deconjugation Effector RavZ Inhibits Host Autophagy Through
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چکیده
, 1072 (2012); 338 Science et al. Augustine Choy Irreversible Atg8 Deconjugation Effector RavZ Inhibits Host Autophagy Through Legionella The This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): November 4, 2014 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/338/6110/1072.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2012/10/24/science.1227026.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/338/6110/1072.full.html#ref-list-1 , 10 of which can be accessed free: cites 25 articles This article http://www.sciencemag.org/content/338/6110/1072.full.html#related-urls 9 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology subject collections: This article appears in the following
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The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.
Eukaryotic cells can use the autophagy pathway to defend against microbes that gain access to the cytosol or reside in pathogen-modified vacuoles. It remains unclear if pathogens have evolved specific mechanisms to manipulate autophagy. Here, we found that the intracellular pathogen Legionella pneumophila could interfere with autophagy by using the bacterial effector protein RavZ to directly un...
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Autophagy is a conserved cellular process involved in the elimination of proteins and organelles. It is also used to combat infection with pathogenic microbes. The intracellular pathogen Legionella pneumophila manipulates autophagy by delivering the effector protein RavZ to deconjugate Atg8/LC3 proteins coupled to phosphatidylethanolamine (PE) on autophagosomal membranes. To understand how RavZ...
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